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In this trial, 748 cognitively healthy elderly adults, aged 70-79 years, were supplemented for two years with a combination of 500 mg/day of DHA and 200 mg/day of eicosapentaenoic acid or with a placebo containing olive oil
It also reduced the accumulation of ROS, MDA, and 4-HNE, while enhancing GSH and NADPH expression and the NADP/NADPH ratio
Many plants with analogous chemical profiles and therapeutic properties are used globally, though they may bear different local names
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These factors motivate transcriptomic and proteomic profiling to detect unanticipated pathway activation, coupled with dose-window optimization to balance metabolic efficacy with system-level perturbations
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