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No matter the reason someone is using these medications, people might experience some gastrointestinal (GI) discomfort, including: Constipation Diarrhea Nausea Vomiting These side effects are most common when people first start treatment or after a recent dosage adjustment

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The magnitude of decrease in K-18 observed with retatrutide 8 mg and 12 mg has been associated with greater odds of histological improvement in previous studies of patients with MASH 33

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