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Tunneling with biologics Fibrotic matrix disruption and biologic activation The tunneling technique is an advanced intralesional method designed to optimize the distribution of bioactive agents throughout the dense fibrotic matrix [9]
Preclinical studies indicate that simultaneous or near-simultaneous administration produces maximal synergy, with synergistic effects declining as the interval between administrations exceeds 15-30 minutes
Its especially relevant for people experiencing high stress, poor sleep, or dietary gaps
However, its high cost, reliance on specialized instrumentation, and limited scalability for large-scale studies pose challenges for routine use in DR biomarker discovery (41)
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