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These molecules cannot directly stimulate T-cells, but they are involved in amplifying the signal derived from the interaction with an antigen via their interaction with other cell surface molecules, thereby leading to T-cell activation ( DPP-4 and Glucose Homeostasis The link between DPP-4 and glucose homeostasis was only identified after the intestinal hormone, glucagon-like peptide-1 (GLP-1) was found to be a DPP-4 substrate

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Clinical trials are composed of carefully selected patients who meet stringent inclusion and exclusion criteria that are specific to the indication and medication being evaluated, such that they are the best candidates to test a new therapy

GLP-1 agonists: a review for emergency clinicians

A comprehensive metabolic panel and complete blood count provide useful baseline data

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