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The methionine cycle metabolites adjust very rapidly to the decreased methionine input reaching new steady states within a few hours
19 A recent study by Xie et al 30 found that intravenous delivery of a transgene encoding soluble Klotho ameliorated cardiac hypertrophy in Klotho-deficient mice
This renders more difficult the identification of pharmacological or environmental strategies targeting this system for extending lifespan and promoting healthy aging which we call healthspan
Dehydration represents another important contributor, as reduced oral intake due to nausea or early satiety combined with gastrointestinal losses can lead to volume depletion
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