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This neuroendocrine pathway is mechanistically distinct from the hypothalamic and gut-brain circuits predominantly engaged by GLP-1 receptor agonists

One small retrospective case series investigated intra-articular BPC-157 injections for knee pain but lacked rigorous methodology, control groups, and long-term follow-up ([6])

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DSIP may also stimulate the endogenous antioxidant system, influencing various enzymatic levels