Some studies confirmed that in neurodegenerative diseases, spermidine also activates mitophagy by enhancing PINK expression, which prolongs lifespan, improves health span, protects against memory loss and increases locomotor activity (Reference Filfan, Olaru and Udristoiu78, Reference Yang, Zhang and Dai79)
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Although the exact pathophysiology of NAION is unknown, it is understood to result from insufficient blood flow to the optic nerve head, the researchers wrote in their paper