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Conclusion As a starting point to inform deeper investigations into real-world variation and patient profiles for responsiveness to therapies, our research bridges the gap between clinical trials and GLP-1 use in the real world, where a broader, more diverse population is using GLP-1s in a variety of settings and personal contexts

GLP-1 mediates regulation of colonic ACE2 expression by the bile acid receptor GPBAR1 in Inflammation

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Another large study showed that using GLP-1s may help prevent immune-related diseases in people with diabetes or obesity People with diabetes who took GLP-1 drugs had a lower chance of developing rheumatoid arthritis, gout, and osteoarthritis compared to people on other diabetes medications

doi: 10.1016/j.dsx.2022.102539 29

Patients and physicians must maintain realistic expectations and provide sustained support throughout the recovery process