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Lenti- RRM2 shRNA vector was constructed using RRM2 shRNA oligonucleotides with LV 2N (U6/Puro) vector

Orally administered semaglutide was administered for 10 consecutive days with dose escalation on the 5th day (5 days of 5 mg dosing followed by five days of 10 mg dosing) to avoid gastrointestinal side effects in both normal and renally impaired subjects

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