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10.2337/diab.32.1.14 120 TaylorS
Thus, microbial changes in PD indicate a shift from a symbiotic, neuroprotective microbiota to a pro-inflammatory, neurotoxic microbial composition, which can promote peripheral immune activation, gut barrier failure, and, eventually, neuroinflammation and dopaminergic neuronal death [44]
Development of drugs characterized by biased activation may enable selective therapy and reduce adverse effects
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