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3.4 Changes in bone turnover markers Figures 1c,d present percentage changes in CTX and P1NP by group and over time, respectively

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Metformin therapy may relieve the clinical symptoms of endometriosis (pelvic pain and menstrual disorders), accompanied by a reduction in the levels of inflammatory cytokines in the serum and peritoneal fluid in women with endometriosis due to its anti-inflammatory effects (Omer, 2016)