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However, it is crucial to acknowledge the potential side effects of these therapies, including gastrointestinal issues, pancreatitis, and the risk of pulmonary aspiration during anaesthesia

[1] The gastrointestinal side effects of tirzepatide, particularly nausea, vomiting, and diarrhea, can sometimes be accompanied by systemic symptoms such as weakness, lightheadedness, or body discomfort

The study demonstrates a distinct activation mechanism for MC4R, offering new insights into G protein coupling and receptor activation at the molecular level

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The economic burden is considerable: annual direct healthcare costs attributable to MASLD in the United States and Europe are estimated in the tens of billions of dollars, driven by hospitalizations, liver-related procedures, and management of comorbid conditions [6]