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While ROS can function as second messengers regulating cellular reproduction, growth, differentiation, and signaling when maintained at optimal concentrations and dynamic equilibrium, exceeding critical ROS thresholds induces oxidative stress, leading to DNA damage, protein denaturation, and lipid peroxidationkey factors in CHD development
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Glutathione undergoes a reaction with the toxic substances, facilitated by enzymes such as glutathione S-transferases, to form a conjugate known as a glutathione adduct, which is then further metabolized in the liver to form mercapturic acid, a water-soluble compound that can be easily excreted through the urine
doi: 10.1155/2016/1287128 189 DorranceAMNevianiPFerenchakGJHuangXNicoletDMaharryKSet al
It can raise blood levels of creatinine (a waste product with a similar name), which can make it look like kidney function is worse, even if its not causing damage
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