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Vitamin B-6 (from Pyridoxine HCl)
In rats, feeding activity and food intake decreased following intracerebroventricular injection of GLP-1, an effect counteracted by co-administration of a GLP-1 receptor antagonist (71, 72), suggesting central GLP-1 as a potent inhibitor of feeding
The two outcomes compound in a way that makes the effort and cost of running both compounds worthwhile compared to running either alone
A 2025 analysis by the Employers Health Coalition found that 64% of large employers (5,000+ employees) excluded GLP-1 medications for obesity from their health plans, citing projected costs of $12,000 to $15,000 per patient per year (Jain et al., Health Affairs 2025)
Sermorelin remains available through compounding pharmacies in both Canada and the United States for off-label adult use
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