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LaccID activity is specific to the mammalian cell surface In mammalian cells, LacAnc100 is active at the cell surface but fusions targeted to the cytosol, mitochondria or endoplasmic reticulum (ER) lumen are inactive (Supplementary Fig

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1 Introduction Cirrhosis represents the advanced stage of chronic inflammatory liver damage, marked by the disruption of intrahepatic vasculature, hepatocyte loss, and extensive scarring

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