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The medication actually appears to preserve lean mass better than many alternatives, with some research suggesting improved muscle quality through reduced muscle fat infiltration

10.1016/j.chembiol.2003.10.003 31 MatsuiJ.HaqueA.HussD.MessanaE.AlosiJ.RobersonD.et al

At a molecular level, higher temperatures increase kinetic energy

MT-2 is non-selective and produces tanning, sexual, and appetite effects

This suggests that the drug does not preferentially target muscle for catabolism, but rather that muscle loss is a bystander effect of the profound weight reduction

Clinical studies demonstrate that weekly administration produces more stable metabolic control than shorter intervals would allow