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Lindstrom J, Louheranta A, Mannelin M, Rastas M, Salminen V, Eriksson J, et al
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2 Cryogenic electron microscopy (CEM) imaging demonstrates that orforglipron binds within the upper helical bundle of GLP-1R and acts as a highly potent partial agonist that favors cyclic adenosine monophosphate (cAMP) signaling over beta-arrestin recruitment
& King, T
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