A single-cell atlas of IL-23 inhibition in cutaneous psoriasis distinguishes clinical response
Within the H-site, the substrate analogue ( 12 ) interacts through hydrogen bonds to N108 and the backbone of V12, a interaction with F112, water bridges to R16 and Y175, and hydrophobic interactions with V12 and V115 (Fig
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For these localized applications, systemic absorption may matter less than direct contact with digestive tissues
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