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The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C-Cdh1

Cellular and Molecular Neurobiology , 44(1), 1-16

Patients often lose around 15% of their body weight on Ozempic/Wegovy, while those Mounjaro/Zepbound may see drops of 20% or more

It is possible that GIP may still be involved in spite of the observations that its actions are impaired in patients with T2DM (42), because it appears that these can be at least partially restored

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Patients should also be counselled about gastrointestinal side effects and the need for fat-soluble vitamin supplementation