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Months 612: Long-Term Progress and Maintenance Many patients continue losing weight throughout the second half of the first year, although the rate of weight loss often slows compared with the earlier months
Measurable body composition changes usually become apparent by weeks 2-4, with progressive improvements continuing through weeks 4-12 of consistent use
SGLT-2 inhibitors: Ketone education, sick-day rules, hydration, and clear stop rules are the non-negotiable foundation for safe use
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This is because the liver partly overlies the stomach and obesity can cause it to become enlarged
19 The dual GIP/GLP-1 RA tirzepatide has demonstrated a similar but sometimes more pronounced GI profile compared with semaglutide in clinical-development programs
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