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Because the liver lacks the enzymes needed to fully make the conversion from folic acid to THF, not all of the folic acid can be changed over to the form the body requires

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Furthermore, compound R487E + V488E mutations, which interfere with the nuclear import of TRIM28, 41 also disrupted nuclear accumulation of TRIM37 (Fig

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The condition affects roughly 1 to 3% of the general adult population, with peak incidence occurring between ages 30 and 50

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