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It's not clear yet which of the many chemicals in coffee is responsible for the benefits
PMID 12006124
Pinning down an exact percentage is difficult because of the many factors involved in measuring nausea in GLP-1 users: GLP-1 in question starting dosage diet dosage compliance use of anti-nausea meds individual definitions of nausea The most comprehensive studies have shown that between 40%65% of GLP-1 patients experience nausea and/or other digestive disturbances, like diarrhea and vomiting
Flohe L, Gunzler WA, Schock HH
In Phase 2 trial data, the most commonly reported adverse effects included: Nausea (reported in a significant proportion of participants, particularly during dose escalation) Vomiting Diarrhoea Constipation Decreased appetite (which, whilst contributing to weight loss, can occasionally be excessive) These effects were generally described as mild to moderate in severity and tended to diminish over time as the body adjusted to the medication
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