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Eli Lilly's investigational once-weekly injectable the first drug candidate to simultaneously activate GIP, GLP-1, and glucagon receptors posted average weight loss of 28.3% at 80 weeks in TRIUMPH-1, its pivotal Phase 3 obesity trial enrolling 2,339 adults

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Many patients also benefit from applying a warm compress 24 hours after injection to increase blood flow and ease residual soreness

Compounded medications are regulated by state Boards of Pharmacy, but are not evaluated by the FDA for safety or efficacy