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One of the confirmed effects is possible dysaesthesia

Gastroenterology 2012;142:1444-6.ArticlePubMed 112

Additionally, 29% had diabetes requiring treatment before surgery

Additionally, oxidative stress significantly impairs RFC function: Low glutathione: Reduces RFC function ~20-40% High nitric oxide: Reduces RFC function ~35% Hyperglycemia: Reduces RFC function ~20-35% Even if you're taking Leucovorin, oxidative stress can prevent it from reaching your brain

(PubMed) Dalmeijer GW, Olthof MR, Verhoef P, Bots ML, van der Schouw YT

Second-order neurons In a neurocircuitry aimed at orchestrating responses to changes in a circulating cue, second-order neurons receive direct synaptic inputs from first-order neurons