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Although the kinetic parameters determined for the l-homocysteine -lyase activity of the mutant are inaccurate because of substrate inhibition, both the K m and k cat values seem to be reduced (Table 1), as was the case for l-cysteine -lyase activity

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However, she expressed disappointment that this led to dropped coverage instead of more efforts toward patient education and encouragement to continue, which she feels was lacking during her journey with her PCP

Treatment-emergent AEs (TEAEs) were defined as events occurring between the dosing day and the follow-up visit +14 days (i.e., up to 5 weeks post-dose, corresponding to five half-lives of semaglutide), or starting before the dosing day with increasing severity during the period

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