problems with glp-1 drugs Long-term Success of GLP-1s Hinges on More Than Just a Prescription Opinion | Should Boston follow

PMID: 36364899

In South Australia, the Controlled Substances Act 1984 (SA) makes it an offence to prescribe, purchase, use, sell or supply peptides without sufficient authorisation

D.GeversD.PedamalluC

Unlike a glitazone medication like Actos (pioglitazone), which improves insulin sensitivity, GLP-1 agonists do not mainly work by directly unlocking insulin resistance the way a sensitizer doesalthough weight loss from GLP-1 therapy can indirectly improve insulin sensitivity

Pickarts work, researchers looking to test GHK-Cu in a wound healing context should administer a total GHK-Cu dose of 100200 mg to produce therapeutic actions, though the necessary effective dosage may be even smaller [5]

Thus, more glutamine in astrocytes may also lead to increased availability of glutamate for the synthesis of GABA, the primary inhibitory neurotransmitter in the brain (Yudkoff et al., 2008)