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This is because overuse can lead to digestive issues, affecting absorption and causing oxidative stress

In addition, the plasma membrane of the cell becomes porous or cracked, which greatly increases the permeability of the plasma membrane and allows free diffusion of ions or soluble substances to the outside

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To overcome the rapid degradation of GLP-1, two approaches have been developed: 1) GLP-1 receptor agonists resistant to DPP-IV metabolism, and 2) DPP-IV inhibitors to augment the effect of native/endogenous GLP-1