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For GLP-1 users, the ideal protocol is a baseline scan before or at the start of therapy, followed by follow-up scans every three months

Third, false-negative analysis is a test that we propose based on the specific situation of this study

In the context of extremely low levels of SAMe, Dnmt3a and Dnmt3b might demethylate 5mC via deamination to thymine, which confirmed the dynamic activity of DNMTs with methyltransferases and demethylases according to the levels of SAMe [67]

In patients with hypertension, coronary disease, arrhythmia, or other cardiovascular risk factors, baseline blood pressure and heart rate monitoring is warranted

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