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For cardiovascular and metabolic benefits, longer treatment durations produce more sustained protection

This is often more effective than trying to "eat" the molecule itself

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Transdermal insulin needs to replicate that precision through a biological barrier that wasn't designed to let it pass

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The article's timeline section describes nausea and gastrointestinal distress beginning within roughly 6 to 24 hours, peaking around 36 to 72 hours, then gradually easing over one to three weeks as tolerance develops