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It also supports weight reduction and cardiovascular risk reduction in certain patients

Who Should Not Switch Patients with active or recent pancreatitis, personal or family history of medullary thyroid carcinoma (MTC), or multiple endocrine neoplasia type 2 (MEN2) should not be initiated on any GLP-1 receptor agonist, including retatrutide [4]

Long-term hyperglycemia is strongly associated with microvascular damage, i.e., neuropathy, nephropathy, and retinopathy, which reduce life expectancy, microvascular complications, and other aspects of quality of life (Singh et al., 2025)

It connects patients with board-certified, licensed providers who evaluate each individual and may prescribe GLP-1 medications when clinically appropriate