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The first step in the process involves the enzyme tyrosine hydroxylase which, like phenylalanine hydroxylase (of tyrosine synthesis), requires tetrahydrobiopterin (BH 4 , or also written H 4 B) as a cofactor

Therefore, p53 is an important therapeutic target for keloids because of its crucial role in regulating apoptosis 7,8

[7] Research has indicated a potential area of interest for DSIP in the study of withdrawal symptoms from opiate and alcohol addictions, which has been supported by the results of studies in animals conducted by Tissot and the fact, that DSIP possesses an agonistic activity on opiate receptors