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In 2019 a multinational collaborative study of data collected in 204 countries and territories between 2000 and 2019 indicated that obesity contributed approximately 5 million deaths from major non-communicable diseases

Subsequently, dual GLP-1 receptor (GLP1-R) and GIP-receptor (GIP-R) agonism is able to reduce BW by more than 20% (35, 36)

Additionally, research data indicate that GINS complex subunit 4 (GINS4), as a promoter of eukaryotic G1/cell cycle, is considered a potential oncogene in LUAD