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This may be due to GLP-1R-mediated upregulation of the sympathetic system, as has recently been demonstrated for central GLP-1R effects on innate immunity 15
In the fields of sports medicine and bodybuilding, it can increase fat burning speed, maintain lean muscle tissue, help athletes and bodybuilders increase muscle mass, reduce fat accumulation, and improve athletic performance and body shape
Moving from insulin to GLP-1 A patient on basal insulin whose Type 2 diabetes is relatively well controlled might transition to a GLP-1 agonist if they are gaining excessive weight on insulin, want to simplify their regimen, have developed cardiovascular risk factors that would benefit from GLP-1 protection, or have adequate remaining beta cell function
If you're planning to conceive, discuss discontinuing GLP-1 therapy with your healthcare provider beforehand
Nat Genet
The review notes, however, that the degree to which these benefits are independent of weight loss may vary by condition, and further research is needed to elucidate these mechanisms fully
