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This is a black box warning for the entire GLP-1 class based on thyroid C-cell tumor findings in rodent studies

Typically, candidates should have a body mass index (BMI) of 30 or higher, categorically defining obesity

GLP-1R signaling regulates brain energy homeostasis and may improve mitochondrial function in depression In addition to the disturbed neuroimmune and neuroendocrine crosstalk, disruptions in brain metabolism and mitochondrial functions seem to be an emergent field of interest in the context of depression pathogenesis

However, as for glucose metabolism, no significant differences in lipid profile (triglycerides, total cholesterol, HDL and LDL cholesterol) were detected between patients with PWS and BMI-matched patients without PWS, likely because patients with PWS have less visceral fat content and this could preserve lipid profile from the detrimental effect of visceral fat excess [35, 36]

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