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In eye diseases like DR, high blood glucose and oxidative stress activate the Notch1-Hes signaling pathway, leading to ECM imbalance and promoting vascular dysfunction, inflammation, and retinal damage ( 2.5 Anti-angiogenic effect Abnormal angiogenesis plays a significant role in the pathogenesis of several eye diseases, particularly those involving retinal ischemia and neovascularization

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However, there was no effect on HDL or LDL levels

Na + changes were not obvious in each group

Diabetes 59 , 17651770 (2010)

[PMID: 8907434] PubMed record related to this compound for laboratory literature review