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Its based on studies of preservative effectiveness and the cumulative risk of contamination from multiple punctures over time
In a 26-week rat oral toxicity study, AOD-9604 produced dose-dependent changes in serum osteocalcin (a bone-turnover marker) at week 13, with the direction reversing by week 26
Figure 1 shows the individual vitamin B12 serum levels before and after treatment for the non-responders and responders
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