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In the AWARD-7 trial (which was not a CVOT) performed in T2DM subjects with moderate-to-severe CKD, once-weekly dulaglutide produced glycemic control similar to that achieved with insulin glargine, but showed evidence of reduced decline in eGFR (64)
These changes may assist short-term outcomes but generate fresh requirements when the drug ends
If you consistently feel worse on injection days, schedule rest days or light activity (walking only) for those days
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Ranimation 2004, 13: 324-333
Repeated compression of the dosing interval increases your average drug exposure beyond what was prescribed, elevates side effect risk, and disrupts the steady-state pharmacokinetics that your body has adapted to
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