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Furthermore, given that NO lasts only a few seconds in tissues due to its unbalanced electrons, both its production and stability depend on extensive antioxidant protection

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Its ongoing evaluation in phase III trials, including combinations with immune checkpoint inhibitors (e.g., pembrolizumab) [LITESPARK-012], underscores the potential of HIF-2 inhibition as a cornerstone in the treatment of hypoxia-driven tumors (195)

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