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In the absence of completed and published phase I/II/III clinical trials, it is impossible to establish a complete profile of potential adverse effects in humans

Inhibition of mitochondrial adaptations and improvements in cardiorespiratory fitness by 50 percent and diminished whole-body insulin sensitivity after aerobic exercise 6 Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults Konopka et al (2018)

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Each component has attracted attention in experimental models related to cellular signaling, tissue remodeling, and regenerative biology

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