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Despite the accumulating evidence around pathways engaged by the GLP-1R and other GPCRs in target tissues, there is still substantial uncertainty about the precise molecular mechanisms engaged, particularly with regards to the spatiotemporal organisation of their signalling and presence in spatially restricted subcellular (and even suborganelle) signalling hubs or nanodomains 61

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delbrueckii correlated with behavioral improvements, says co-corresponding author Honghong Yao, also of Southeast University

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D), the stress hormone cortisol, and sex hormones such as testosterone and estrogen [5]

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