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TH potentiates the production of non-12-OH FXR-antagonistic BAs Recent evidence suggests that a couple of non-12-OH BAs, including T(/)MCA, (T/G)UDCA, and (T)HDCA, can exert FXR-antagonistic effects 4,9,10,29 , while intestinal FXR inhibition is able to stimulate GLP-1 production and secretion in L cell 11

Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells

Magnesium glycinate is preferred for muscle symptoms due to superior absorption and minimal gastrointestinal side effects

Safety Considerations Most common adverse effects: Nausea Vomiting Diarrhea GI intolerance Rare but important: Pancreatitis Gallbladder disease Potential thyroid C-cell concerns in animal models Careful patient selection and dose titration remain essential

RUO stands for Research Use Only

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