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The Phase 2 trial ran for 48 weeks with continuous dosing
The enhancement of Nrf2 transcription with sulforaphane or melatonin could benefit patients with LONG COVID (Post-Acute Sequelae of SARS-CoV-2 or Post-COVID-Syndrome), a significant proportion (approximately 40%) of individuals with COVID-19 experiencing a variety of symptoms (loss of smell and/or taste, fatigue, cough, aching pain, brain fog, insomnia, shortness of breath, and tachycardia) after 12 weeks (Jarrott et al., 2022
refer to BNF guidance and the SmPC for analogous agents
The action of ghrelin, at the level of increasing the release of NPY, is the exact opposite to that of leptin which inhibits NPY release
These mechanisms work identically in men and women
Weight loss associated with treatment can improve mobility, sleep quality, and exercise tolerance, contributing to better energy levels
