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Hepatic effects that are considered adverse include death, abnormal clinical chemistry parameters, obvious functional organ impairment, DNA and mitochondrial alteration, glutathione depletion, hepatocyte necrosis, enhanced replicative DNA synthesis, generation of reactive oxygen species, and increased peroxisome proliferation (in rodents) (Williams and Iatropoulos 2002)

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Some genes get upregulated

But what about alcohol, does it affect your glutathione levels

The constants in this equation are not known with sufficient accuracy, causing errors in the extrapolation to become larger at higher temperatures