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In mouse models of Alzheimer's disease, systemic administration of GHK-Cu for 12 weeks results in 30% improvement in cognitive function tests and 25% reduction in brain amyloid plaque burden compared to vehicle-treated controls

When interpreted together with the findings of the STEP 4 withdrawal trial and STEP 1 off-treatment extension study, which both showed weight regain after semaglutide discontinuation (after 20 weeks treatment in STEP 4 and 68 weeks treatment in STEP 1) 23,24 , these results support the benefit of continued semaglutide treatment for sustained weight loss

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The team next examined whether the protective effect would appear in living muscle