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The effectiveness of semaglutide GLP-1 can be enhanced when combined with lifestyle interventions, such as a balanced diet and regular physical activity

The drug performed better on all secondary endpoints as well, including a greater percentage of people losing at least 15% of their weight (roughly a third of those on the highest dose achieved this)

It works best as an adjunct combined with in-clinic treatments rather than on its own

Nature communications 2025

Employers that cover GLP-1s for obesity said theyll put more hurdles around their use, such as requiring prescriptions from specific providers and requiring users to participate in weight management programs

Sodium gluconate is water-soluble