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Berberine, an alkaloid compound derived from plants like barberry and goldenseal, has demonstrated modest metabolic effects in research studies

It is a key supplement for people suffering from pernicious anemia, and for vegetarians and vegans that have vitamin B12 deficiencies related to dietary choices

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In the cases of 15 g and 20 g doses the liver concentration of GSH stays very low for an extended period of time

However, if the purpose of the drug is to be taken up by the liver, then first-pass metabolism may be irrelevant (the drug is still metabolized into hepatic glutathione, which is what matters)

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