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An altered intestinal barrier function can also be a result of host physiological factors (e.g., bile acids) and environmental factors (e.g., dietary components) and is not necessarily deleterious, leading to a disease phenotype

Berger, C

Because organelle contacts are highly dynamic, transient and structurally complex, a major bottleneck in the field is that no single technique can simultaneously capture high-resolution architecture, rapid temporal changes, and the comprehensive proteomic landscape

This decline affects sleep quality, circadian regulation, and downstream hormonal systems

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