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doi: 10.2174/157488910791213130 85 HolscherC

7.6 Hydration and Electrolytes GLP-1 therapy may reduce thirst perception in some individuals

Where This Paper Deserves Skepticism The underlying evidence base is thin: 12 studies, 146 participants, and only seven independent cohorts, with some studies sharing overlapping participants

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This suggests that GLP-1R-mediated food-intake control pathways have a degree of redundancy, supported by the fact that GLP-1R null animals exhibit limited phenotypic consequences (199)