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Flavonoids are important because they act as free-radical scavengers and antioxidants, exhibiting anti-mutagenic, anti-inflammatory, and antiviral effects[and] are able to reduce plasma levels of low-density lipoproteins, inhibit platelet aggregation, and reduce cell proliferation. (Salehi, 2019)

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The classical complement cascade mediates CNS synapse elimination

As humans do not produce TMCA, we examined the levels of non-12-OH FXR-antagonistic BA species in humans, and found that the levels of non-12-OH FXR-antagonistic BAs (HDCA and UDCA-related species) were positively correlated with T3 levels in euthyroid human study participants (Fig

Which tissues respond best (muscle, endocrine, kidney, brain)

Shin WS, Xie F, Chen B, Yu P, Yu J, To KF, et al