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Physiologically, this is often the result of sarcopenia (muscle wasting) combined with rapid fat loss in the facial pads
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One 55-year-old wound up in the ER with a 30-hour erection after injecting 2 milligrams into his abdomen
Endocrinology 153:10391048 Wild D, von Maltzahn R, Brohan E, Christensen T, Clauson P, Gonder-Frederick L (2007) A critical review of the literature on fear of hypoglycemia in diabetes: implications for diabetes management and patient education
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